Top Weight Loss Injections – 2025

Ozempic® is FDA-approved for treating type 2 diabetes. Its active ingredient, semaglutide, is a glucagon-like peptide-1 (GLP-1) receptor agonist that works like the naturally occurring GLP-1 hormone released during eating. This hormone signals fullness to the brain, delays stomach emptying, and lowers blood sugar. Available by prescription only, Ozempic® is taken once weekly as an injection to help with blood sugar control and reduce cardiovascular risks in people with type 2 diabetes. Although not FDA-approved solely for weight loss in people without diabetes, studies show semaglutide can lead to significant weight reduction in individuals with overweight or obesity.

Wegovy® contains the same active ingredient as Ozempic® but is FDA-approved specifically for chronic weight management. It is intended for adults with a BMI of 27 or higher with at least one weight-related condition, or those with a BMI of 30 or higher. Like Ozempic®, it is available only by prescription and administered as a once-weekly injection. Clinical studies have shown Wegovy® to be effective in helping patients achieve and maintain meaningful weight loss when combined with lifestyle changes.

Saxenda® is a GLP-1 receptor agonist made with liraglutide instead of semaglutide. FDA-approved for chronic weight management, it is available by prescription for adults with a BMI of 30 or higher, or those with a BMI of 27 or more with a weight-related health condition. Saxenda® is also approved for adolescents aged 12 and older weighing more than 132 pounds. It is taken as a daily injection and works by reducing appetite and slowing stomach emptying, which can help lower calorie intake and promote weight loss.